Colts vs. 49ers prediction, odds, start time: Monda...

What’s Happening

Let’s talk about The SportsLine projection model has spilled its Indianapolis Colts vs.

San Francisco 49ers picks for the 2025 NFL Week 16 Monday Night Football game Colts vs. 49ers prediction, odds, start time: ‘Monday Night Football’ picks, best bets from proven model The SportsLine projection model has spilled its Indianapolis Colts vs. (we’re not making this up)

The Niners (10-4) have clutched four straight, all of them coming , including a 37-24 win over Tennessee in Week 15.

The Details

The Colts (8-6), meanwhile, are riding a four-game losing streak and fell to Seattle, 18-16, last week. Quarterback Philip Rivers, who came out of retirement last week following Daniel Jones’ Achilles injury, will start again for the Colts with rookie Riley Leonard backing him up.

Cornerback Sauce Gardner (calf) is out for Indianapolis. ET from Lucas Oil Stadium in Indianapolis.

Why This Matters

Colts odds from DraftKings Sportsbook have San Francisco as the 5. 5-point road favorite, while the over/under for total points scored is 46. 49ers picks, be sure to see the NFL predictions from SportsLine’s projection model .

The sports world never stops delivering these kinds of storylines.

Key Takeaways

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception.
The model enters Week 16 on a 52-37 run on top-rated picks dating back to 2024.
Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.
Now, the model has zeroed in on San Francisco vs.