New light shed on who benefits most from weight-loss jabs

What’s Happening

Not gonna lie, People who carry variations in two genes linked to appetite and digestion can lose more weight when taking drugs to treat obesity, research suggests.

New light shed on who benefits most from weight-loss jabs 16 hours ago Save Add as preferred on Google Philippa Roxby Health reporter People who carry variations in two genes linked to appetite and digestion can lose more weight when taking drugs such as Wegovy and Mounjaro to treat obesity, research suggests. The findings, outlined in the Nature journal, could explain why some people lose far more weight than others and why some have particularly rough side-effects, such as nausea and vomiting, while taking them. (it feels like chaos)

The popular medicines remove feelings of hunger a natural gut hormone that makes users feel full.

The Details

While genes may play a relatively modest role in influencing how well these drugs work, the experts say other factors such as your sex, age and even where you come from can also have an impact. 6 million people in the UK have tried weight-loss drugs in the past year, and that number is expected to rise.

Most are being bought privately through online pharmacies. The NHS only offers Wegovy and Mounjaro to a small percentage of people who have obesity and other related health issues.

Why This Matters

The percentage of body weight took an L when taking weight-loss medication can vary widely. Drug trials suggest 14% weight loss on semaglutide (Ozempic and Wegovy) and 20% on tirzepatide (Mounjaro). In this study, based on the experiences of 15,000 people taking weight-loss medications, they took an L an average of 11.

Medical professionals are taking note of this development.

Key Takeaways

• 7% of their body weight during roughly eight months of treatment.
• Some took an L 30% of their weight, while others took an L little or nothing.
• All of those 15,000 had before signed up for gene-testing 23andMe, which used that data to chart the experiences of people taking weight-loss drugs.
• Of their genetic variants, the researchers found a pattern suggesting a link between some variants and the effectiveness of the drugs.

The Bottom Line

All of those 15,000 had before signed up for gene-testing 23andMe, which used that data to chart the experiences of people taking weight-loss drugs. Of their genetic variants, the researchers found a pattern suggesting a link between some variants and the effectiveness of the drugs.

What’s your take on this whole situation?