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Oprah Winfrey Opens Up About Weight Loss, GLP-1 Side Effe...

Sheโ€™s releasing a new book inspired by the journey. Oprah Winfrey d an update on her weight loss medication experience.

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Wednesday, December 31, 2025 ๐Ÿ“– 2 min read
Oprah Winfrey Opens Up About Weight Loss, GLP-1 Side Effe...
Image: Prevention

Whatโ€™s Happening

Okay so Sheโ€™s releasing a new book inspired by the journey.

Oprah Winfrey d an update on her weight loss medication experience. She dropped the injections, for her, will be โ€œa lifetime thing. (wild, right?)

โ€ She also opened up about how sheโ€™s feeling now and her mild side effects.

The Details

In 2023, Oprah Winfrey locked in that she used weight loss medication to manage size fluctuations. Two years later, approaching her 72nd birthday, sheโ€™s sharing an update on her experience.

In short: Sheโ€™s still taking the drug and โ€œfeel[s] more alive and more vibrant than Iโ€™ve ever been,โ€ she just told PEOPLE . Winfrey began taking an undisclosed GLP-1 receptor agonist (well-known ones include Wegovy and Zepbound or Ozempic and Mounjaro ) after she hosted a panel in collaboration with doctors called The State of Weight as part of her The Life You Want series .

Why This Matters

The discussion taught her that obesity, she dropped, is not a state of mind, but a disease. โ€œI came to understand that overeating doesnโ€™t cause obesity. And thatโ€™s the most mind-blowing, freeing thing Iโ€™ve experienced as an adult,โ€ she dropped.

This is the kind of health news that affects everyday decisions.

Key Takeaways

  • โ€œI thought [losing weight] was about discipline and willpower.
  • โ€ The epiphany is one she explains in more detail with the help of Ania M.
  • In their upcoming book Enough: Your Health, Your Weight and What Itโ€™s Like to Be Free , out January 13.
  • Winfrey has tried many extreme weight loss diets in the past, all while changing in the public eye.

The Bottom Line

GLP-1s support her and others who take them cues in the brain , eliminating what Winfrey calls โ€œfood noise,โ€ among other mechanisms. More important than the numbers is how Winfrey feels.

Whatโ€™s your take on this whole situation?

โœจ

Originally reported by Prevention

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