Self-learning AI releases NFL picks, score predictions ev...

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Breaking it down: SportsLine AI evaluated the Week 17 NFL odds and spilled its NFL score predictions and best NFL picks Self-learning AI releases NFL picks, score predictions every Week 17 game SportsLine AI evaluated the Week 17 NFL odds and spilled its NFL score predictions and best NFL picks By Daniel Kohn Dec 26, 2025 at 12:44 pm ET • 2 min read Join the Conversation comments Imagn Images The NFL Week 17 schedule rolls on with two more games on Saturday 10 on Sunday and then the standard ‘Monday Night Football’ slot.

Several of the remaining games have a direct bearing on the NFL playoffs and seeding. In the NFC, the NFC West-leading Seattle Seahawks take on the NFC South-leading Carolina Panthers. (yes, really)

Seattle enters as a 7-point favorite at DraftKings Sportsbook.

The Details

In the AFC South, the division-leading Jacksonville Jaguars take on the Indianapolis Colts. Sunday’s largest spread is Patriots (-13.

Jets, while another larger spread is on ‘Monday Night Football,’ with the Rams (-8) vs. The smallest spreads Sunday include Giants vs.

Why This Matters

49ers (-3) on ‘Sunday Night Football. ’ Seattle entered the weekend as the NFC’s top seed, while Denver remains first in the AFC after its Christmas Day win over the Chiefs. Before making any Week 17 NFL picks or NFL score predictions on those games or others, you need to see the NFL against the spread, over/under and money line predictions powered -learning SportsLine AI .

This could change the dynamics of the sport going forward.

Key Takeaways

• Built using cutting-edge AI and ML techniques by SportsLine’s Data Science team, AI Predictions and AI Ratings are generated for each game.
• It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines.
• SportsLine’s AI PickBot has hit more than 2,000 4.

The Bottom Line

It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine’s AI PickBot has hit more than 2,000 4.

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